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Thermodynamic, Computational Solubility Parameters in Organic Solvents and In Silico GastroPlus Based Prediction of Ketoconazole

[Image: see text] The study aimed to select a suitable solvent capable to solubilize ketoconazole (KETO) and serve as a permeation enhancer across the skin. Experimental solubility and Hansen solubility parameters were obtained in ethanol, dimethyl sulfoxide (DMSO), ethylene glycol, oleic acid, span...

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Detalles Bibliográficos
Autores principales: Alshehri, Sultan, Hussain, Afzal, Ahsan, Mohd Neyaz, Ali, Raisuddin, Siddique, Mohd Usman Mohd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7905953/
https://www.ncbi.nlm.nih.gov/pubmed/33644612
http://dx.doi.org/10.1021/acsomega.0c06234