Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms

The serum iron level in humans is tightly controlled by the action of the hormone hepcidin on the iron efflux transporter ferroportin. Hepcidin regulates iron absorption and recycling by inducing ferroportin internalization and degradation(1). Aberrant ferroportin activity can lead to diseases of ir...

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Detalles Bibliográficos
Autores principales: Billesbølle, Christian B., Azumaya, Caleigh M., Kretsch, Rachael C., Powers, Alexander S., Gonen, Shane, Schneider, Simon, Arvedson, Tara, Dror, Ron O., Cheng, Yifan, Manglik, Aashish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906036/
https://www.ncbi.nlm.nih.gov/pubmed/32814342
http://dx.doi.org/10.1038/s41586-020-2668-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906036/
https://www.ncbi.nlm.nih.gov/pubmed/32814342
http://dx.doi.org/10.1038/s41586-020-2668-z

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