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The age pattern of the male-to-female ratio in mortality from COVID-19 mirrors that of cardiovascular disease in the general population

Males are at a higher risk of dying from COVID-19 than females. Older age and cardiovascular disease are also associated with COVID-19 mortality. To better understand how age and sex interact (in) contributing to COVID-19 mortality, we stratified the male-to-female (sex) ratios in mortality by age g...

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Autores principales: Nimgaonkar, Ila, Valeri, Linda, Susser, Ezra, Hussain, Sabiha, Sunderram, Jag, Aviv, Abraham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906174/
https://www.ncbi.nlm.nih.gov/pubmed/33550276
http://dx.doi.org/10.18632/aging.202639
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author Nimgaonkar, Ila
Valeri, Linda
Susser, Ezra
Hussain, Sabiha
Sunderram, Jag
Aviv, Abraham
author_facet Nimgaonkar, Ila
Valeri, Linda
Susser, Ezra
Hussain, Sabiha
Sunderram, Jag
Aviv, Abraham
author_sort Nimgaonkar, Ila
collection PubMed
description Males are at a higher risk of dying from COVID-19 than females. Older age and cardiovascular disease are also associated with COVID-19 mortality. To better understand how age and sex interact (in) contributing to COVID-19 mortality, we stratified the male-to-female (sex) ratios in mortality by age group. We then compared the age-stratified sex ratios with those of cardiovascular mortality and cancer mortality in the general population. Data were obtained from official government sources in the US and five European countries: Italy, Spain, France, Germany, and the Netherlands. The sex ratio of deaths from COVID-19 exceeded one throughout adult life, increasing up to a peak in midlife, and declining markedly in later life. This pattern was also observed for the sex ratio of deaths from cardiovascular disease, but not cancer, in the general populations of the US and European countries. Therefore, the sex ratios of deaths from COVID-19 and from cardiovascular disease share similar patterns across the adult life course. The underlying mechanisms are poorly understood and warrant further investigation.
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spelling pubmed-79061742021-03-04 The age pattern of the male-to-female ratio in mortality from COVID-19 mirrors that of cardiovascular disease in the general population Nimgaonkar, Ila Valeri, Linda Susser, Ezra Hussain, Sabiha Sunderram, Jag Aviv, Abraham Aging (Albany NY) Research Paper Males are at a higher risk of dying from COVID-19 than females. Older age and cardiovascular disease are also associated with COVID-19 mortality. To better understand how age and sex interact (in) contributing to COVID-19 mortality, we stratified the male-to-female (sex) ratios in mortality by age group. We then compared the age-stratified sex ratios with those of cardiovascular mortality and cancer mortality in the general population. Data were obtained from official government sources in the US and five European countries: Italy, Spain, France, Germany, and the Netherlands. The sex ratio of deaths from COVID-19 exceeded one throughout adult life, increasing up to a peak in midlife, and declining markedly in later life. This pattern was also observed for the sex ratio of deaths from cardiovascular disease, but not cancer, in the general populations of the US and European countries. Therefore, the sex ratios of deaths from COVID-19 and from cardiovascular disease share similar patterns across the adult life course. The underlying mechanisms are poorly understood and warrant further investigation. Impact Journals 2021-02-07 /pmc/articles/PMC7906174/ /pubmed/33550276 http://dx.doi.org/10.18632/aging.202639 Text en Copyright: © 2021 Nimgaonkar et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Nimgaonkar, Ila
Valeri, Linda
Susser, Ezra
Hussain, Sabiha
Sunderram, Jag
Aviv, Abraham
The age pattern of the male-to-female ratio in mortality from COVID-19 mirrors that of cardiovascular disease in the general population
title The age pattern of the male-to-female ratio in mortality from COVID-19 mirrors that of cardiovascular disease in the general population
title_full The age pattern of the male-to-female ratio in mortality from COVID-19 mirrors that of cardiovascular disease in the general population
title_fullStr The age pattern of the male-to-female ratio in mortality from COVID-19 mirrors that of cardiovascular disease in the general population
title_full_unstemmed The age pattern of the male-to-female ratio in mortality from COVID-19 mirrors that of cardiovascular disease in the general population
title_short The age pattern of the male-to-female ratio in mortality from COVID-19 mirrors that of cardiovascular disease in the general population
title_sort age pattern of the male-to-female ratio in mortality from covid-19 mirrors that of cardiovascular disease in the general population
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906174/
https://www.ncbi.nlm.nih.gov/pubmed/33550276
http://dx.doi.org/10.18632/aging.202639
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