Hedgehog proteins create a dynamic cholesterol interface

During formation of the Hedgehog (Hh) signaling proteins, cooperative activities of the Hedgehog INTein (Hint) fold and Sterol Recognition Region (SRR) couple autoproteolysis to cholesterol ligation. The cholesteroylated Hh morphogens play essential roles in embryogenesis, tissue regeneration, and t...

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Detalles Bibliográficos
Autores principales: Mafi, Amirhossein, Purohit, Rahul, Vielmas, Erika, Lauinger, Alexa R., Lam, Brandon, Cheng, Yu-Shiuan, Zhang, Tianyi, Huang, Yiran, Kim, Soo-Kyung, Goddard, William A., Ondrus, Alison E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906309/
https://www.ncbi.nlm.nih.gov/pubmed/33630857
http://dx.doi.org/10.1371/journal.pone.0246814

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906309/
https://www.ncbi.nlm.nih.gov/pubmed/33630857
http://dx.doi.org/10.1371/journal.pone.0246814

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