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Hedgehog proteins create a dynamic cholesterol interface
During formation of the Hedgehog (Hh) signaling proteins, cooperative activities of the Hedgehog INTein (Hint) fold and Sterol Recognition Region (SRR) couple autoproteolysis to cholesterol ligation. The cholesteroylated Hh morphogens play essential roles in embryogenesis, tissue regeneration, and t...
Autores principales: | Mafi, Amirhossein, Purohit, Rahul, Vielmas, Erika, Lauinger, Alexa R., Lam, Brandon, Cheng, Yu-Shiuan, Zhang, Tianyi, Huang, Yiran, Kim, Soo-Kyung, Goddard, William A., Ondrus, Alison E. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906309/ https://www.ncbi.nlm.nih.gov/pubmed/33630857 http://dx.doi.org/10.1371/journal.pone.0246814 |
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