A “ligand-targeting” peptide-drug conjugate: Targeted intracellular drug delivery by VEGF-binding helix-loop-helix peptides via receptor-mediated endocytosis

As a new alternative to antibody-drug conjugates, we generated “ligand-targeting” peptide-drug conjugates (PDCs), which utilize receptor-mediated endocytosis for targeted intracellular drug delivery. The PDC makes a complex with an extracellular ligand and then binds to the receptor on the cell surf...

Descripción completa

Detalles Bibliográficos
Autores principales: Michigami, Masataka, Takahashi, Kentaro, Yamashita, Haruna, Ye, Zhengmao, Nakase, Ikuhiko, Fujii, Ikuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906330/
https://www.ncbi.nlm.nih.gov/pubmed/33630870
http://dx.doi.org/10.1371/journal.pone.0247045

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906330/
https://www.ncbi.nlm.nih.gov/pubmed/33630870
http://dx.doi.org/10.1371/journal.pone.0247045

Ejemplares similares