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A “ligand-targeting” peptide-drug conjugate: Targeted intracellular drug delivery by VEGF-binding helix-loop-helix peptides via receptor-mediated endocytosis

As a new alternative to antibody-drug conjugates, we generated “ligand-targeting” peptide-drug conjugates (PDCs), which utilize receptor-mediated endocytosis for targeted intracellular drug delivery. The PDC makes a complex with an extracellular ligand and then binds to the receptor on the cell surf...

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Detalles Bibliográficos
Autores principales:	Michigami, Masataka, Takahashi, Kentaro, Yamashita, Haruna, Ye, Zhengmao, Nakase, Ikuhiko, Fujii, Ikuo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906330/ https://www.ncbi.nlm.nih.gov/pubmed/33630870 http://dx.doi.org/10.1371/journal.pone.0247045

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