Repressing Ago2 mRNA translation by Trim71 maintains pluripotency through inhibiting let-7 microRNAs

The regulation of stem cell fate is poorly understood. Genetic studies in Caenorhabditis elegans lead to the hypothesis that a conserved cytoplasmic double-negative feedback loop consisting of the RNA-binding protein Trim71 and the let-7 microRNA controls the pluripotency and differentiation of stem...

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Detalles Bibliográficos
Autores principales: Liu, Qiuying, Chen, Xiaoli, Novak, Mariah K, Zhang, Shaojie, Hu, Wenqian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906602/
https://www.ncbi.nlm.nih.gov/pubmed/33599613
http://dx.doi.org/10.7554/eLife.66288

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906602/
https://www.ncbi.nlm.nih.gov/pubmed/33599613
http://dx.doi.org/10.7554/eLife.66288

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