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Dynamic effects of genetic variation on gene expression revealed following hypoxic stress in cardiomyocytes

One life-threatening outcome of cardiovascular disease is myocardial infarction, where cardiomyocytes are deprived of oxygen. To study inter-individual differences in response to hypoxia, we established an in vitro model of induced pluripotent stem cell-derived cardiomyocytes from 15 individuals. We...

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Detalles Bibliográficos
Autores principales: Ward, Michelle C, Banovich, Nicholas E, Sarkar, Abhishek, Stephens, Matthew, Gilad, Yoav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906610/
https://www.ncbi.nlm.nih.gov/pubmed/33554857
http://dx.doi.org/10.7554/eLife.57345