IRGM1 links mitochondrial quality control to autoimmunity

Mitochondrial abnormalities have been noted in lupus, but the causes and consequences remain obscure. Autophagy-related genes ATG5, ATG7, and IRGM have been previously implicated in autoimmune disease. We reasoned that failure to clear defective mitochondria via mitophagy might be a foundational dri...

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Detalles Bibliográficos
Autores principales: Rai, Prashant, Janardhan, Kyathanahalli S., Meacham, Julie, Madenspacher, Jennifer H., Lin, Wan-Chi, Karmaus, Peer W.F., Martinez, Jennifer, Li, Quan-Zhen, Yan, Mei, Zeng, Jialiu, Grinstaff, Mark W., Shirihai, Orian S., Taylor, Gregory A., Fessler, Michael B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906953/
https://www.ncbi.nlm.nih.gov/pubmed/33510463
http://dx.doi.org/10.1038/s41590-020-00859-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906953/
https://www.ncbi.nlm.nih.gov/pubmed/33510463
http://dx.doi.org/10.1038/s41590-020-00859-0

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