Pirfenidone Is a Vasodilator: Involvement of K(V)7 Channels in the Effect on Endothelium-Dependent Vasodilatation in Type-2 Diabetic Mice

Endothelial cell dysfunction and fibrosis are associated with worsening of the prognosis in patients with cardiovascular disease. Pirfenidone has a direct antifibrotic effect, but vasodilatation may also contribute to the effects of pirfenidone. Therefore, in a first study we investigated the mechan...

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Detalles Bibliográficos
Autores principales: Beck, Lilliana, Pinilla, Estéfano, Arcanjo, Daniel Dias Rufino, Hernanz, Raquel, Prat-Duran, Judit, Petersen, Asbjørn Graver, Köhler, Ralf, Sheykhzade, Majid, Comerma-Steffensen, Simon, Simonsen, Ulf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906977/
https://www.ncbi.nlm.nih.gov/pubmed/33643042
http://dx.doi.org/10.3389/fphar.2020.619152

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906977/
https://www.ncbi.nlm.nih.gov/pubmed/33643042
http://dx.doi.org/10.3389/fphar.2020.619152

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