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Adipose-derived mesenchymal stem cells differentiate into heterogeneous cancer-associated fibroblasts in a stroma-rich xenograft model

Cancer-associated fibroblasts (CAFs) are the key components of the densely proliferated stroma in pancreatic ductal adenocarcinoma (PDAC) and contribute to tumor progression and drug resistance. CAFs comprise heterogeneous subpopulations playing unique and vital roles. However, the commonly used mou...

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Detalles Bibliográficos
Autores principales: Miyazaki, Yoshihiro, Oda, Tatsuya, Inagaki, Yuki, Kushige, Hiroko, Saito, Yutaka, Mori, Nobuhito, Takayama, Yuzo, Kumagai, Yutaro, Mitsuyama, Toutai, Kida, Yasuyuki S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907195/
https://www.ncbi.nlm.nih.gov/pubmed/33633222
http://dx.doi.org/10.1038/s41598-021-84058-3