Specific domain V reduction of beta-2-glycoprotein I induces protein flexibility and alters pathogenic antibody binding

Beta-2-glycoprotein I (β2GPI) is a blood protein and the major antigen in the autoimmune disorder antiphospholipid syndrome (APS). β2GPI exists mainly in closed or open conformations and comprises of 11 disulfides distributed across five domains. The terminal Cys288/Cys326 disulfide bond at domain V...

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Detalles Bibliográficos
Autores principales: Buchholz, Ina, McDonnell, Thomas, Nestler, Peter, Tharad, Sudarat, Kulke, Martin, Radziszewska, Anna, Ripoll, Vera M., Schmidt, Frank, Hammer, Elke, Toca-Herrera, Jose L., Rahman, Anisur, Delcea, Mihaela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907366/
https://www.ncbi.nlm.nih.gov/pubmed/33633190
http://dx.doi.org/10.1038/s41598-021-84021-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907366/
https://www.ncbi.nlm.nih.gov/pubmed/33633190
http://dx.doi.org/10.1038/s41598-021-84021-2

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