Multifaceted Mechanism of Amicoumacin A Inhibition of Bacterial Translation

Amicoumacin A (Ami) halts bacterial growth by inhibiting the ribosome during translation. The Ami binding site locates in the vicinity of the E-site codon of mRNA. However, Ami does not clash with mRNA, rather stabilizes it, which is relatively unusual and implies a unique way of translation inhibit...

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Detalles Bibliográficos
Autores principales: Maksimova, Elena M., Vinogradova, Daria S., Osterman, Ilya A., Kasatsky, Pavel S., Nikonov, Oleg S., Milón, Pohl, Dontsova, Olga A., Sergiev, Petr V., Paleskava, Alena, Konevega, Andrey L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907450/
https://www.ncbi.nlm.nih.gov/pubmed/33643246
http://dx.doi.org/10.3389/fmicb.2021.618857

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907450/
https://www.ncbi.nlm.nih.gov/pubmed/33643246
http://dx.doi.org/10.3389/fmicb.2021.618857

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