Cargando…

Pleckstrin homology domain of phospholipase D2 is a negative regulator of focal adhesion kinase

Phospholipase D2 (PLD2) has been implicated in the tyrosine kinase-mediated signaling pathways, but the regulation events are yet to be identified. Herein, we demonstrate that pleckstrin homology (PH) domain of PLD2 (PLD2-PH) exerts an antitumorigenic effect via the suppression of PLD2 and focal adh...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Mi Kyoung, Hwang, Won Chan, Min, Do Sik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Society for Biochemistry and Molecular Biology 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907743/ https://www.ncbi.nlm.nih.gov/pubmed/32843133 http://dx.doi.org/10.5483/BMBRep.2021.54.2.154

Ejemplares similares

The pleckstrin homology domain of phospholipase D1 accelerates EGFR endocytosis by increasing the expression of the Rab5 effector, rabaptin-5
por: Park, Mi Hee, et al.
Publicado: (2015)

Membrane and Protein Interactions of the Pleckstrin Homology Domain Superfamily
por: Lenoir, Marc, et al.
Publicado: (2015)

Systematic simulation of the interactions of pleckstrin homology domains with membranes
por: Le Huray, Kyle I. P., et al.
Publicado: (2022)

Rac Regulates Its Effector Phospholipase Cγ(2) through Interaction with a Split Pleckstrin Homology Domain
por: Walliser, Claudia, et al.
Publicado: (2008)

Bacterial Pleckstrin Homology Domains: A Prokaryotic Origin for the PH Domain
por: Xu, Qingping, et al.
Publicado: (2010)

Structural and Functional Characterization of the Kindlin-1 Pleckstrin Homology Domain
por: Yates, Luke A., et al.
Publicado: (2012)

The pleckstrin-homology domain of dynamin is dispensable for membrane constriction and fission
por: Dar, Srishti, et al.
Publicado: (2017)

Lipid-targeting pleckstrin homology domain turns its autoinhibitory face toward the TEC kinases
por: Amatya, Neha, et al.
Publicado: (2019)

Structural basis of wedging the Golgi membrane by FAPP pleckstrin homology domains
por: Lenoir, Marc, et al.
Publicado: (2010)

The oncogenic mutation in the pleckstrin homology domain of AKT1 in endometrial carcinomas
por: Shoji, K, et al.
Publicado: (2009)

Structure and lipid-binding properties of the kindlin-3 pleckstrin homology domain
por: Ni, Tao, et al.
Publicado: (2017)

Biophysical and Computational Studies of Membrane Penetration by the GRP1 Pleckstrin Homology Domain
por: Lumb, Craig N., et al.
Publicado: (2011)

Alternate pleckstrin homology domain orientations regulate dynamin-catalyzed membrane fission
por: Mehrotra, Niharika, et al.
Publicado: (2014)

Molecular Insights into the Regulation of 3-Phosphoinositide-Dependent Protein Kinase 1: Modeling the Interaction between the Kinase and the Pleckstrin Homology Domains
por: Garcia-Viloca, Mireia, et al.
Publicado: (2022)

Role of Phosphatidylinositol 3′ Kinase and a Downstream Pleckstrin Homology Domain–Containing Protein in Controlling Chemotaxis inDictyostelium
por: Funamoto, Satoru, et al.
Publicado: (2001)

Role of the pleckstrin homology domain of PLCγ1 in its interaction with the insulin receptor
por: Kwon, Yong-Kook, et al.
Publicado: (2003)

IQSEC2‐related encephalopathy in males due to missense variants in the pleckstrin homology domain
por: Shoubridge, Cheryl, et al.
Publicado: (2022)

Pleckstrin Homology Domain of Akt Kinase: A Proof of Principle for Highly Specific and Effective Non-Enzymatic Anti-Cancer Target
por: Joh, Eun-Ha, et al.
Publicado: (2012)

Inhibition of phospholipase D2 induces autophagy in colorectal cancer cells
por: Hwang, Won Chan, et al.
Publicado: (2014)

Pleckstrin homology domain-containing protein PHLDB3 supports cancer growth via a negative feedback loop involving p53
por: Chao, Tengfei, et al.
Publicado: (2016)

Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14
por: Depetris, Rafael S, et al.
Publicado: (2009)

Specialized structural and functional roles of residues selectively conserved in subfamilies of the pleckstrin homology domain family
por: Naveenkumar, Nagarajan, et al.
Publicado: (2019)

Flexible pivoting of dynamin pleckstrin homology domain catalyzes fission: insights into molecular degrees of freedom
por: Baratam, Krishnakanth, et al.
Publicado: (2021)

Substitution of the myristoylation signal of human immunodeficiency virus type 1 Pr55(Gag) with the phospholipase C-δ1 pleckstrin homology domain results in infectious pseudovirion production
por: Urano, Emiko, et al.
Publicado: (2008)

Hadp1, a newly identified pleckstrin homology domain protein, is required for cardiac contractility in zebrafish
por: Wythe, Joshua D., et al.
Publicado: (2011)

Interactions of Pleckstrin Homology Domains with Membranes: Adding Back the Bilayer via High-Throughput Molecular Dynamics
por: Yamamoto, Eiji, et al.
Publicado: (2016)

Regulation of Cdc42 Gtpase by Proline-Rich Tyrosine Kinase 2 Interacting with Psgap, a Novel Pleckstrin Homology and Src Homology 3 Domain Containing Rhogap Protein
por: Ren, Xiu-Rong, et al.
Publicado: (2001)

Novel Role for Pleckstrin Homology‐Like Domain Family A, Member 3 in the Regulation of Pathological Cardiac Hypertrophy
por: Liu, Jia, et al.
Publicado: (2019)

Mechanistic analysis of a novel membrane-interacting variable loop in the pleckstrin-homology domain critical for dynamin function
por: Khurana, Himani, et al.
Publicado: (2023)

Focal adhesion kinase-dependent focal adhesion recruitment of SH2 domains directs SRC into focal adhesions to regulate cell adhesion and migration
por: Wu, Jui-Chung, et al.
Publicado: (2015)

The fission yeast pleckstrin homology domain protein Spo7 is essential for initiation of forespore membrane assembly and spore morphogenesis
por: Nakamura-Kubo, Michiko, et al.
Publicado: (2011)

Crystal Structure of the Pleckstrin Homology Domain from the Ceramide Transfer Protein: Implications for Conformational Change upon Ligand Binding
por: Prashek, Jennifer, et al.
Publicado: (2013)

Novel Inhibitors Induce Large Conformational Changes of GAB1 Pleckstrin Homology Domain and Kill Breast Cancer Cells
por: Chen, Lu, et al.
Publicado: (2015)

Insights into the inhibitory mechanism of triazole-based small molecules on phosphatidylinositol-4,5-bisphosphate binding pleckstrin homology domain
por: Gorai, Sukhamoy, et al.
Publicado: (2015)

Structural and biochemical characterization of the pleckstrin homology domain of the RhoGEF P-Rex2 and its regulation by PIP(3)
por: Cash, Jennifer N., et al.
Publicado: (2018)

The expression patterns and prognostic significance of pleckstrin homology-like domain family A (PHLDA) in lung cancer and malignant mesothelioma
por: Baldavira, Camila M., et al.
Publicado: (2021)

A Novel Pleckstrin Homology Domain-containing Protein Enhances Insulin-stimulated Akt Phosphorylation and GLUT4 Translocation in Adipocytes
por: Zhou, Qiong L., et al.
Publicado: (2010)

Cancer Associated E17K Mutation Causes Rapid Conformational Drift in AKT1 Pleckstrin Homology (PH) Domain
por: Kumar, Ambuj, et al.
Publicado: (2013)

A Pathogenic Homozygous Mutation in The Pleckstrin Homology Domain of RASA1 Is Responsible for Familial Tricuspid Atresia in An Iranian Consanguineous Family
por: Nozari, Ahoura, et al.
Publicado: (2019)

A proline-rich motif in the large intracellular loop of the glycine receptor α1 subunit interacts with the Pleckstrin homology domain of collybistin
por: Breitinger, Ulrike, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_meh73ift5mig4e4469oiuo5h7o