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Determination of dimethylamine and nitrite in pharmaceuticals by ion chromatography to assess the likelihood of nitrosamine formation

Since July 2018 several drugs have been recalled due to contamination with N-nitrosodimethylamine (NDMA), a probable human carcinogen. Dimethylamine (DMA) and nitrite are precursors in the formation of NDMA. In this study, ion chromatography (IC) methods were developed for the determination of these...

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Detalles Bibliográficos
Autores principales: Hu, Jingli, Christison, Terri, Rohrer, Jeffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907779/
https://www.ncbi.nlm.nih.gov/pubmed/33665410
http://dx.doi.org/10.1016/j.heliyon.2021.e06179