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Determination of dimethylamine and nitrite in pharmaceuticals by ion chromatography to assess the likelihood of nitrosamine formation

Since July 2018 several drugs have been recalled due to contamination with N-nitrosodimethylamine (NDMA), a probable human carcinogen. Dimethylamine (DMA) and nitrite are precursors in the formation of NDMA. In this study, ion chromatography (IC) methods were developed for the determination of these...

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Detalles Bibliográficos
Autores principales:	Hu, Jingli, Christison, Terri, Rohrer, Jeffrey
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907779/ https://www.ncbi.nlm.nih.gov/pubmed/33665410 http://dx.doi.org/10.1016/j.heliyon.2021.e06179

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