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Selective postnatal excitation of neocortical pyramidal neurons results in distinctive behavioral and circuit deficits in adulthood
In genetic and pharmacological models of neurodevelopmental disorders, and human data, neural activity is altered within the developing neocortical network. This commonality begs the question of whether early enhancement in excitation might be a common driver, across etiologies, of characteristic be...
Autores principales: | Medendorp, William E., Bjorefeldt, Andreas, Crespo, Emmanuel L., Prakash, Mansi, Pal, Akash, Waddell, Madison L., Moore, Christopher I., Hochgeschwender, Ute |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907816/ https://www.ncbi.nlm.nih.gov/pubmed/33665575 http://dx.doi.org/10.1016/j.isci.2021.102157 |
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