Lymphopenia-induced lymphoproliferation drives activation of naive T cells and expansion of regulatory populations

Chemotherapy pre-conditioning is an essential component of chimeric antigen receptor transduced cell therapy. Acute lymphopenia-induced proliferation (LIP) is known to be driven primarily by homeostatic cytokines, but little is known on the underlying mechanisms in humans. We undertook phenotypic an...

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Detalles Bibliográficos
Autores principales: S, Eldershaw, K, Verma, W, Croft, T, Rai, FAM, Kinsella, C, Stephens, H, Chen, J, Nunnick, J, Zuo, R, Malladi, P, Moss
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907823/
https://www.ncbi.nlm.nih.gov/pubmed/33665580
http://dx.doi.org/10.1016/j.isci.2021.102164

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907823/
https://www.ncbi.nlm.nih.gov/pubmed/33665580
http://dx.doi.org/10.1016/j.isci.2021.102164

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