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Lymphopenia-induced lymphoproliferation drives activation of naive T cells and expansion of regulatory populations
Chemotherapy pre-conditioning is an essential component of chimeric antigen receptor transduced cell therapy. Acute lymphopenia-induced proliferation (LIP) is known to be driven primarily by homeostatic cytokines, but little is known on the underlying mechanisms in humans. We undertook phenotypic an...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907823/ https://www.ncbi.nlm.nih.gov/pubmed/33665580 http://dx.doi.org/10.1016/j.isci.2021.102164 |