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Simulating the effect of cerebral blood flow changes on regional quantification of [(18)F]flutemetamol and [(18)F]florbetaben studies

Global and regional changes in cerebral blood flow (CBF) can result in biased quantitative estimates of amyloid load by PET imaging. Therefore, the current simulation study assessed effects of these changes on amyloid quantification using a reference tissue approach for [(18)F]flutemetamol and [(18)...

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Autores principales: Heeman, Fiona, Yaqub, Maqsood, Lopes Alves, Isadora, Heurling, Kerstin, Bullich, Santiago, Gispert, Juan D, Boellaard, Ronald, Lammertsma, Adriaan A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907983/
https://www.ncbi.nlm.nih.gov/pubmed/32281514
http://dx.doi.org/10.1177/0271678X20918029
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author Heeman, Fiona
Yaqub, Maqsood
Lopes Alves, Isadora
Heurling, Kerstin
Bullich, Santiago
Gispert, Juan D
Boellaard, Ronald
Lammertsma, Adriaan A
author_facet Heeman, Fiona
Yaqub, Maqsood
Lopes Alves, Isadora
Heurling, Kerstin
Bullich, Santiago
Gispert, Juan D
Boellaard, Ronald
Lammertsma, Adriaan A
author_sort Heeman, Fiona
collection PubMed
description Global and regional changes in cerebral blood flow (CBF) can result in biased quantitative estimates of amyloid load by PET imaging. Therefore, the current simulation study assessed effects of these changes on amyloid quantification using a reference tissue approach for [(18)F]flutemetamol and [(18)F]florbetaben. Previously validated pharmacokinetic rate constants were used to simulate time-activity curves (TACs) corresponding to full dynamic and dual-time-window acquisition protocols. CBF changes were simulated by varying the tracer delivery (K(1)) from +25 to −25%. The standardized uptake value ratio (SUVr) was computed and TACs were fitted using reference Logan (RLogan) and the simplified reference tissue model (SRTM) to obtain the relative delivery rate (R(1)) and volume of distribution ratio (DVR). RLogan was least affected by CBF changes (χ(2) = 583 p < 0.001, χ(2) = 81 p < 0.001, for [(18)F]flutemetamol and [(18)F]florbetaben, respectively) and the extent of CBF sensitivity generally increased for higher levels of amyloid. Further, SRTM-derived R(1) changes correlated well with simulated CBF changes (R(2) > 0.95) and SUVr’s sensitivity to CBF changes improved for later uptake-times, with the exception of [(18)F]flutemetamol cortical changes. In conclusion, RLogan is the preferred method for amyloid quantification of [(18)F]flutemetamol and [(18)F]florbetaben studies and SRTM could be additionally used for obtaining a CBF proxy.
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spelling pubmed-79079832021-03-11 Simulating the effect of cerebral blood flow changes on regional quantification of [(18)F]flutemetamol and [(18)F]florbetaben studies Heeman, Fiona Yaqub, Maqsood Lopes Alves, Isadora Heurling, Kerstin Bullich, Santiago Gispert, Juan D Boellaard, Ronald Lammertsma, Adriaan A J Cereb Blood Flow Metab Original Articles Global and regional changes in cerebral blood flow (CBF) can result in biased quantitative estimates of amyloid load by PET imaging. Therefore, the current simulation study assessed effects of these changes on amyloid quantification using a reference tissue approach for [(18)F]flutemetamol and [(18)F]florbetaben. Previously validated pharmacokinetic rate constants were used to simulate time-activity curves (TACs) corresponding to full dynamic and dual-time-window acquisition protocols. CBF changes were simulated by varying the tracer delivery (K(1)) from +25 to −25%. The standardized uptake value ratio (SUVr) was computed and TACs were fitted using reference Logan (RLogan) and the simplified reference tissue model (SRTM) to obtain the relative delivery rate (R(1)) and volume of distribution ratio (DVR). RLogan was least affected by CBF changes (χ(2) = 583 p < 0.001, χ(2) = 81 p < 0.001, for [(18)F]flutemetamol and [(18)F]florbetaben, respectively) and the extent of CBF sensitivity generally increased for higher levels of amyloid. Further, SRTM-derived R(1) changes correlated well with simulated CBF changes (R(2) > 0.95) and SUVr’s sensitivity to CBF changes improved for later uptake-times, with the exception of [(18)F]flutemetamol cortical changes. In conclusion, RLogan is the preferred method for amyloid quantification of [(18)F]flutemetamol and [(18)F]florbetaben studies and SRTM could be additionally used for obtaining a CBF proxy. SAGE Publications 2020-04-11 2021-03 /pmc/articles/PMC7907983/ /pubmed/32281514 http://dx.doi.org/10.1177/0271678X20918029 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Articles
Heeman, Fiona
Yaqub, Maqsood
Lopes Alves, Isadora
Heurling, Kerstin
Bullich, Santiago
Gispert, Juan D
Boellaard, Ronald
Lammertsma, Adriaan A
Simulating the effect of cerebral blood flow changes on regional quantification of [(18)F]flutemetamol and [(18)F]florbetaben studies
title Simulating the effect of cerebral blood flow changes on regional quantification of [(18)F]flutemetamol and [(18)F]florbetaben studies
title_full Simulating the effect of cerebral blood flow changes on regional quantification of [(18)F]flutemetamol and [(18)F]florbetaben studies
title_fullStr Simulating the effect of cerebral blood flow changes on regional quantification of [(18)F]flutemetamol and [(18)F]florbetaben studies
title_full_unstemmed Simulating the effect of cerebral blood flow changes on regional quantification of [(18)F]flutemetamol and [(18)F]florbetaben studies
title_short Simulating the effect of cerebral blood flow changes on regional quantification of [(18)F]flutemetamol and [(18)F]florbetaben studies
title_sort simulating the effect of cerebral blood flow changes on regional quantification of [(18)f]flutemetamol and [(18)f]florbetaben studies
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907983/
https://www.ncbi.nlm.nih.gov/pubmed/32281514
http://dx.doi.org/10.1177/0271678X20918029
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