7-Fluorosialyl Glycosides Are Hydrolysis Resistant but Readily Assembled by Sialyltransferases Providing Easy Access to More Metabolically Stable Glycoproteins

[Image: see text] The maintenance of therapeutic glycoproteins within the circulatory system is associated, in large part, with the integrity of sialic acids as terminal sugars on the glycans. Glycoprotein desialylation, either by spontaneous cleavage or through host sialidases, leads to protein cle...

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Detalles Bibliográficos
Autores principales: Geissner, Andreas, Baumann, Lars, Morley, Thomas J., Wong, Andrew K. O., Sim, Lyann, Rich, Jamie R., So, Pauline P. L., Dullaghan, Edie M., Lessard, Etienne, Iqbal, Umar, Moreno, Maria, Wakarchuk, Warren W., Withers, Stephen G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7908025/
https://www.ncbi.nlm.nih.gov/pubmed/33655072
http://dx.doi.org/10.1021/acscentsci.0c01589

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7908025/
https://www.ncbi.nlm.nih.gov/pubmed/33655072
http://dx.doi.org/10.1021/acscentsci.0c01589

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