LRRK2 inhibition potentiates PARP inhibitor cytotoxicity through inhibiting homologous recombination‐mediated DNA double strand break repair

PARP inhibitors induce DNA lesions, the repair of which are highly dependent on homologous recombination (HR), and preferentially kill HR‐ deficient cancers. However, cancer cells have developed several mechanisms to transform HR and confer drug resistance to PARP inhibition. Therefore, there is a g...

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Detalles Bibliográficos
Autores principales: Chen, Lifeng, Hou, Jing, Zeng, Xiangyu, Guo, Qiang, Deng, Min, Kloeber, Jake A, Tu, Xinyi, Zhao, Fei, Wu, Zheming, Huang, Jinzhou, Luo, Kuntian, Kim, Wootae, Lou, Zhenkun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7908045/
https://www.ncbi.nlm.nih.gov/pubmed/33784003
http://dx.doi.org/10.1002/ctm2.341

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7908045/
https://www.ncbi.nlm.nih.gov/pubmed/33784003
http://dx.doi.org/10.1002/ctm2.341

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