Cargando…

LRRK2 inhibition potentiates PARP inhibitor cytotoxicity through inhibiting homologous recombination‐mediated DNA double strand break repair

PARP inhibitors induce DNA lesions, the repair of which are highly dependent on homologous recombination (HR), and preferentially kill HR‐ deficient cancers. However, cancer cells have developed several mechanisms to transform HR and confer drug resistance to PARP inhibition. Therefore, there is a g...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Lifeng, Hou, Jing, Zeng, Xiangyu, Guo, Qiang, Deng, Min, Kloeber, Jake A, Tu, Xinyi, Zhao, Fei, Wu, Zheming, Huang, Jinzhou, Luo, Kuntian, Kim, Wootae, Lou, Zhenkun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7908045/ https://www.ncbi.nlm.nih.gov/pubmed/33784003 http://dx.doi.org/10.1002/ctm2.341

Ejemplares similares

A novel UCHL(3) inhibitor, perifosine, enhances PARP inhibitor cytotoxicity through inhibition of homologous recombination-mediated DNA double strand break repair
por: Song, Zhiwang, et al.
Publicado: (2019)

The deubiquitinase USP36 Regulates DNA replication stress and confers therapeutic resistance through PrimPol stabilization
por: Yan, Yuanliang, et al.
Publicado: (2020)

USP52 regulates DNA end resection and chemosensitivity through removing inhibitory ubiquitination from CtIP
por: Gao, Ming, et al.
Publicado: (2020)

Syk-dependent alternative homologous recombination activation promotes cancer resistance to DNA targeted therapy
por: Zhou, Qin, et al.
Publicado: (2023)

DNA end resection and its role in DNA replication and DSB repair choice in mammalian cells
por: Zhao, Fei, et al.
Publicado: (2020)

RNF19A-mediated ubiquitination of BARD1 prevents BRCA1/BARD1-dependent homologous recombination
por: Zhu, Qian, et al.
Publicado: (2021)

Aurora-A expressing tumour cells are deficient for homology-directed DNA double strand-break repair and sensitive to PARP inhibition
por: Sourisseau, Tony, et al.
Publicado: (2010)

The bromodomain containing protein BRD-9 orchestrates RAD51–RAD54 complex formation and regulates homologous recombination-mediated repair
por: Zhou, Qin, et al.
Publicado: (2020)

Author Correction: The bromodomain containing protein BRD-9 orchestrates RAD51–RAD54 complex formation and regulates homologous recombination-mediated repair
por: Zhou, Qin, et al.
Publicado: (2022)

PARP inhibition versus PARP-1 silencing: different outcomes in terms of single-strand break repair and radiation susceptibility
por: Godon, Camille, et al.
Publicado: (2008)

Dynamic recruitment of UFM1-specific peptidase 2 to the DNA double-strand breaks regulated by WIP1
por: Qin, Bo, et al.
Publicado: (2022)

PARP retains Ku at double-strand breaks
por: Short, Ben
Publicado: (2011)

Reciprocal regulation of RIG-I and XRCC4 connects DNA repair with RIG-I immune signaling
por: Guo, Guijie, et al.
Publicado: (2021)

Mutation in DDM1 inhibits the homology directed repair of double strand breaks
por: Choi, Seung Hee, et al.
Publicado: (2019)

Deciphering the functional mechanism of zinc ions of PARP1 binding with single strand breaks and double strand breaks
por: Sun, Shuya, et al.
Publicado: (2022)

Ubiquitin and ubiquitin-like molecules in DNA double strand break repair
por: Yu, Jia, et al.
Publicado: (2020)

A Lamin-Binding Ligand Inhibits Homologous Recombination Repair of DNA Double-Strand Breaks
por: Li, Bingbing X., et al.
Publicado: (2018)

ZFP161 regulates replication fork stability and maintenance of genomic stability by recruiting the ATR/ATRIP complex
por: Kim, Wootae, et al.
Publicado: (2019)

ARF induction in response to DNA strand breaks is regulated by PARP1
por: Orlando, Giulia, et al.
Publicado: (2014)

CDK-mediated RNF4 phosphorylation regulates homologous recombination in S-phase
por: Luo, Kuntian, et al.
Publicado: (2015)

Inhibition of double-strand break non-homologous end-joining by cisplatin adducts in human cell extracts
por: Diggle, C. P., et al.
Publicado: (2005)

Bora Downregulation Results in Radioresistance by Promoting Repair of Double Strand Breaks
por: Cairns, Junmei, et al.
Publicado: (2015)

Alkyladenine DNA glycosylase deficiency uncouples alkylation-induced strand break generation from PARP-1 activation and glycolysis inhibition
por: Alhumaydhi, Fahad A., et al.
Publicado: (2020)

PARP Inhibition in Prostate Cancer With Homologous Recombination Repair Alterations
por: von Werdt, Alexander, et al.
Publicado: (2021)

Inhibiting DNA-PKcs in a non-homologous end-joining pathway in response to DNA double-strand breaks
por: Dong, Jun, et al.
Publicado: (2017)

IGF-1R inhibition enhances radiosensitivity and delays double-strand break repair by both non-homologous end-joining and homologous recombination
por: Chitnis, Meenali M., et al.
Publicado: (2013)

Suppression of homology-dependent DNA double-strand break repair induces PARP inhibitor sensitivity in VHL-deficient human renal cell carcinoma
por: Scanlon, Susan E., et al.
Publicado: (2017)

Excess Single-Stranded DNA Inhibits Meiotic Double-Strand Break Repair
por: Johnson, Rebecca, et al.
Publicado: (2007)

PARP regulates nonhomologous end joining through retention of Ku at double-strand breaks
por: Couto, C. Anne-Marie, et al.
Publicado: (2011)

Structural Basis of Detection and Signaling of DNA Single-Strand Breaks by Human PARP-1
por: Eustermann, Sebastian, et al.
Publicado: (2015)

PARP inhibition impedes the maturation of nascent DNA strands during DNA replication
por: Vaitsiankova, Alina, et al.
Publicado: (2022)

Single-molecule force spectroscopy reveals binding and bridging dynamics of PARP1 and PARP2 at DNA double-strand breaks
por: Bell, Nicholas A. W., et al.
Publicado: (2023)

m6A demethylation of cytidine deaminase APOBEC3B mRNA orchestrates arsenic-induced mutagenesis
por: Gao, Ming, et al.
Publicado: (2022)

Breaking the Iron Homeostasis: A “Trojan Horse” Self-Assembled Nanodrug Sensitizes Homologous Recombination Proficient Ovarian Cancer Cells to PARP Inhibition
por: Li, Yangyang, et al.
Publicado: (2022)

Maintaining Genome Integrity: Protein Kinases and Phosphatases Orchestrate the Balancing Act of DNA Double-Strand Breaks Repair in Cancer
por: Qin, Sisi, et al.
Publicado: (2023)

The Role of DNA Double-Strand Breaks in Spontaneous Homologous Recombination in S. cerevisiae
por: Lettier, Gaëlle, et al.
Publicado: (2006)

Impaired DNA double-strand break repair and effective radiosensitization of HPV-negative HNSCC cell lines through combined inhibition of PARP and Wee1
por: Oetting, Agnes, et al.
Publicado: (2023)

PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways
por: Wang, Minli, et al.
Publicado: (2006)

Ku counteracts mobilization of PARP1 and MRN in chromatin damaged with DNA double-strand breaks
por: Cheng, Qiao, et al.
Publicado: (2011)

Poly(ADP-ribose) polymerase (PARP-1) is not involved in DNA double-strand break recovery
por: Noël, Georges, et al.
Publicado: (2003)

Cannot write session to /tmp/vufind_sessions/sess_jvdb3bkk97flkslm73d84uq022