Chromatin remodeling by the histone methyltransferase EZH2 drives lung pre-malignancy and is a target for cancer prevention

BACKGROUND: Trimethylation of lysine 27 and dimethylation of lysine 9 of histone-H3 catalyzed by the histone methyltransferases EZH2 and G9a impede gene transcription in cancer. Our human bronchial epithelial (HBEC) pre-malignancy model studied the role of these histone modifications in transformati...

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Detalles Bibliográficos
Autores principales: Tellez, Carmen S., Picchi, Maria A., Juri, Daniel, Do, Kieu, Desai, Dhimant H., Amin, Shantu G., Hutt, Julie A., Filipczak, Piotr T., Belinsky, Steven A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7908796/
https://www.ncbi.nlm.nih.gov/pubmed/33632299
http://dx.doi.org/10.1186/s13148-021-01034-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7908796/
https://www.ncbi.nlm.nih.gov/pubmed/33632299
http://dx.doi.org/10.1186/s13148-021-01034-4

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