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Chromatin remodeling by the histone methyltransferase EZH2 drives lung pre-malignancy and is a target for cancer prevention

BACKGROUND: Trimethylation of lysine 27 and dimethylation of lysine 9 of histone-H3 catalyzed by the histone methyltransferases EZH2 and G9a impede gene transcription in cancer. Our human bronchial epithelial (HBEC) pre-malignancy model studied the role of these histone modifications in transformati...

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Detalles Bibliográficos
Autores principales:	Tellez, Carmen S., Picchi, Maria A., Juri, Daniel, Do, Kieu, Desai, Dhimant H., Amin, Shantu G., Hutt, Julie A., Filipczak, Piotr T., Belinsky, Steven A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7908796/ https://www.ncbi.nlm.nih.gov/pubmed/33632299 http://dx.doi.org/10.1186/s13148-021-01034-4

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