Cross-species identification of PIP5K1-, splicing- and ubiquitin-related pathways as potential targets for RB1-deficient cells

The RB1 tumor suppressor is recurrently mutated in a variety of cancers including retinoblastomas, small cell lung cancers, triple-negative breast cancers, prostate cancers, and osteosarcomas. Finding new synthetic lethal (SL) interactions with RB1 could lead to new approaches to treating cancers wi...

Descripción completa

Detalles Bibliográficos
Autores principales: Parkhitko, Andrey A., Singh, Arashdeep, Hsieh, Sharon, Hu, Yanhui, Binari, Richard, Lord, Christopher J., Hannenhalli, Sridhar, Ryan, Colm J., Perrimon, Norbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7909629/
https://www.ncbi.nlm.nih.gov/pubmed/33591981
http://dx.doi.org/10.1371/journal.pgen.1009354

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7909629/
https://www.ncbi.nlm.nih.gov/pubmed/33591981
http://dx.doi.org/10.1371/journal.pgen.1009354

Ejemplares similares