Late-stage stitching enabled by manganese-catalyzed C─H activation: Peptide ligation and access to cyclopeptides

Bioorthogonal late-stage diversification of structurally complex peptides bears enormous potential for drug discovery and molecular imaging. Despite major accomplishments, these strategies heavily rely on noble-metal catalysis. Herein, we report on a manganese(I)-catalyzed peptide C─H hydroarylation...

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Detalles Bibliográficos
Autores principales: Kaplaneris, Nikolaos, Kaltenhӓuser, Felix, Sirvinskaite, Giedre, Fan, Shuang, De Oliveira, Tiago, Conradi, Lena-Christin, Ackermann, Lutz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7909873/
https://www.ncbi.nlm.nih.gov/pubmed/33637533
http://dx.doi.org/10.1126/sciadv.abe6202

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7909873/
https://www.ncbi.nlm.nih.gov/pubmed/33637533
http://dx.doi.org/10.1126/sciadv.abe6202

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