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Late-stage stitching enabled by manganese-catalyzed C─H activation: Peptide ligation and access to cyclopeptides
Bioorthogonal late-stage diversification of structurally complex peptides bears enormous potential for drug discovery and molecular imaging. Despite major accomplishments, these strategies heavily rely on noble-metal catalysis. Herein, we report on a manganese(I)-catalyzed peptide C─H hydroarylation...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7909873/ https://www.ncbi.nlm.nih.gov/pubmed/33637533 http://dx.doi.org/10.1126/sciadv.abe6202 |