Combinatorial CRISPR screen identifies fitness effects of gene paralogues

Genetic redundancy has evolved as a way for human cells to survive the loss of genes that are single copy and essential in other organisms, but also allows tumours to survive despite having highly rearranged genomes. In this study we CRISPR screen 1191 gene pairs, including paralogues and known and...

Descripción completa

Detalles Bibliográficos
Autores principales: Thompson, Nicola A., Ranzani, Marco, van der Weyden, Louise, Iyer, Vivek, Offord, Victoria, Droop, Alastair, Behan, Fiona, Gonçalves, Emanuel, Speak, Anneliese, Iorio, Francesco, Hewinson, James, Harle, Victoria, Robertson, Holly, Anderson, Elizabeth, Fu, Beiyuan, Yang, Fengtang, Zagnoli-Vieira, Guido, Chapman, Phil, Del Castillo Velasco-Herrera, Martin, Garnett, Mathew J., Jackson, Stephen P., Adams, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910459/
https://www.ncbi.nlm.nih.gov/pubmed/33637726
http://dx.doi.org/10.1038/s41467-021-21478-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910459/
https://www.ncbi.nlm.nih.gov/pubmed/33637726
http://dx.doi.org/10.1038/s41467-021-21478-9

Ejemplares similares