VPS34 K29/K48 branched ubiquitination governed by UBE3C and TRABID regulates autophagy, proteostasis and liver metabolism

The ubiquitin–proteasome system (UPS) and autophagy are two major quality control processes whose impairment is linked to a wide variety of diseases. The coordination between UPS and autophagy remains incompletely understood. Here, we show that ubiquitin ligase UBE3C and deubiquitinating enzyme TRAB...

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Detalles Bibliográficos
Autores principales: Chen, Yu-Hsuan, Huang, Tzu-Yu, Lin, Yu-Tung, Lin, Shu-Yu, Li, Wen-Hsin, Hsiao, Hsiang-Jung, Yan, Ruei-Liang, Tang, Hong-Wen, Shen, Zhao-Qing, Chen, Guang-Chao, Wu, Kuen-Phon, Tsai, Ting-Fen, Chen, Ruey-Hwa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910580/
https://www.ncbi.nlm.nih.gov/pubmed/33637724
http://dx.doi.org/10.1038/s41467-021-21715-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910580/
https://www.ncbi.nlm.nih.gov/pubmed/33637724
http://dx.doi.org/10.1038/s41467-021-21715-1

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