Tuning flavin environment to detect and control light-induced conformational switching in Drosophila cryptochrome

Light-induction of an anionic semiquinone (SQ) flavin radical in Drosophila cryptochrome (dCRY) alters the dCRY conformation to promote binding and degradation of the circadian clock protein Timeless (TIM). Specific peptide ligation with sortase A attaches a nitroxide spin-probe to the dCRY C-termin...

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Detalles Bibliográficos
Autores principales: Chandrasekaran, Siddarth, Schneps, Connor M., Dunleavy, Robert, Lin, Changfan, DeOliveira, Cristina C., Ganguly, Abir, Crane, Brian R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910608/
https://www.ncbi.nlm.nih.gov/pubmed/33637846
http://dx.doi.org/10.1038/s42003-021-01766-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910608/
https://www.ncbi.nlm.nih.gov/pubmed/33637846
http://dx.doi.org/10.1038/s42003-021-01766-2

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