Syntaxin 1A Gene Is Negatively Regulated in a Cell/Tissue Specific Manner by YY1 Transcription Factor, Which Binds to the −183 to −137 Promoter Region Together with Gene Silencing Factors Including Histone Deacetylase

The HPC-1/syntaxin 1A (Stx1a) gene, which is involved in synaptic transmission and neurodevelopmental disorders, is a TATA-less gene with several transcription start sites. It is activated by the binding of Sp1 and acetylated histone H3 to the −204 to +2 core promoter region (CPR) in neuronal cell/t...

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Detalles Bibliográficos
Autores principales: Nakayama, Takahiro, Fukutomi, Toshiyuki, Terao, Yasuo, Akagawa, Kimio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910890/
https://www.ncbi.nlm.nih.gov/pubmed/33498722
http://dx.doi.org/10.3390/biom11020146

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910890/
https://www.ncbi.nlm.nih.gov/pubmed/33498722
http://dx.doi.org/10.3390/biom11020146

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