Effect of Humanizing Mutations on the Stability of the Llama Single-Domain Variable Region

In vivo clinical applications of nanobodies (VHHs) require molecules that induce minimal immunoresponse and therefore possess sequences as similar as possible to the human VH domain. Although the relative sequence variability in llama nanobodies has been used to identify scaffolds with partially hum...

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Detalles Bibliográficos
Autores principales: Soler, Miguel A., Medagli, Barbara, Wang, Jiewen, Oloketuyi, Sandra, Bajc, Gregor, Huang, He, Fortuna, Sara, de Marco, Ario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911018/
https://www.ncbi.nlm.nih.gov/pubmed/33530572
http://dx.doi.org/10.3390/biom11020163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911018/
https://www.ncbi.nlm.nih.gov/pubmed/33530572
http://dx.doi.org/10.3390/biom11020163

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