Inhibition of HER Receptors Reveals Distinct Mechanisms of Compensatory Upregulation of Other HER Family Members: Basis for Acquired Resistance and for Combination Therapy

Overexpression of members of the HER/erbB transmembrane tyrosine kinase family like HER2/erbB2/neu is associated with various cancers. Some heterodimers, especially HER2/HER3 heterodimers, are particularly potent inducers of oncogenic signaling. Still, from a clinical viewpoint their inhibition has...

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Detalles Bibliográficos
Autores principales: Gutsch, Daniela, Jenke, Robert, Büch, Thomas, Aigner, Achim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911202/
https://www.ncbi.nlm.nih.gov/pubmed/33572976
http://dx.doi.org/10.3390/cells10020272

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911202/
https://www.ncbi.nlm.nih.gov/pubmed/33572976
http://dx.doi.org/10.3390/cells10020272

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