Sulfated Polysaccharides from Macroalgae Are Potent Dual Inhibitors of Human ATP-Hydrolyzing Ectonucleotidases NPP1 and CD39

Extracellular ATP mediates proinflammatory and antiproliferative effects via activation of P2 nucleotide receptors. In contrast, its metabolite, the nucleoside adenosine, is strongly immunosuppressive and enhances tumor proliferation and metastasis. The conversion of ATP to adenosine is catalyzed by...

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Detalles Bibliográficos
Autores principales: Lopez, Vittoria, Schäkel, Laura, Schuh, H. J. Maximilian, Schmidt, Michael S., Mirza, Salahuddin, Renn, Christian, Pelletier, Julie, Lee, Sang-Yong, Sévigny, Jean, Alban, Susanne, Bendas, Gerd, Müller, Christa E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911304/
https://www.ncbi.nlm.nih.gov/pubmed/33499103
http://dx.doi.org/10.3390/md19020051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911304/
https://www.ncbi.nlm.nih.gov/pubmed/33499103
http://dx.doi.org/10.3390/md19020051

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