Cargando…

Development of Fatty Acid Reference Ranges and Relationship with Lipid Biomarkers in Middle-Aged Healthy Singaporean Men and Women

Dietary fatty acids (FA) are essential for overall human health, yet individual FA reference ranges have yet to be established. Developing individual FA reference ranges can provide context to reported concentrations and whether an individual displays deficient, or excess amounts of FA. Reference ra...

Descripción completa

Detalles Bibliográficos
Autores principales: Lust, Cody A. C., Bi, Xinyan, Henry, Christiani Jeyakumar, Ma, David W. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911367/
https://www.ncbi.nlm.nih.gov/pubmed/33572735
http://dx.doi.org/10.3390/nu13020435
_version_ 1783656324740939776
author Lust, Cody A. C.
Bi, Xinyan
Henry, Christiani Jeyakumar
Ma, David W. L.
author_facet Lust, Cody A. C.
Bi, Xinyan
Henry, Christiani Jeyakumar
Ma, David W. L.
author_sort Lust, Cody A. C.
collection PubMed
description Dietary fatty acids (FA) are essential for overall human health, yet individual FA reference ranges have yet to be established. Developing individual FA reference ranges can provide context to reported concentrations and whether an individual displays deficient, or excess amounts of FA. Reference ranges of sixty-seven individual FA (μmol/L) were profiled and analyzed using gas chromatography with a flame ionization detector from serum samples collected from 476 middle-aged Singaporean males (BMI:23.3 ± 2.9) and females (BMI:21.8 ± 3.6). Measures of triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and total cholesterol (TC) (mmol/L) were also collected. The mean FA concentration seen in this cohort (11,458 ± 2478 was similar to that of overweight North American cohorts assessed in past studies. Ten biologically relevant FA were compared between sexes, with females exhibiting significantly higher concentrations in four FA (p < 0.05). A multiple regression model revealed the ten FA contributed significantly to nearly all lipid biomarkers (p < 0.05). A majority of participants who had FA concentrations in the ≥95th percentile also exhibited TG, HDL, LDL, and TC levels in the “high” risk classification of developing cardiovascular disease. Future studies profiling individual FA reference ranges in many unique, global cohorts are necessary to develop cut-off values of individual FA concentrations highly related to disease-risk.
format Online
Article
Text
id pubmed-7911367
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-79113672021-02-28 Development of Fatty Acid Reference Ranges and Relationship with Lipid Biomarkers in Middle-Aged Healthy Singaporean Men and Women Lust, Cody A. C. Bi, Xinyan Henry, Christiani Jeyakumar Ma, David W. L. Nutrients Article Dietary fatty acids (FA) are essential for overall human health, yet individual FA reference ranges have yet to be established. Developing individual FA reference ranges can provide context to reported concentrations and whether an individual displays deficient, or excess amounts of FA. Reference ranges of sixty-seven individual FA (μmol/L) were profiled and analyzed using gas chromatography with a flame ionization detector from serum samples collected from 476 middle-aged Singaporean males (BMI:23.3 ± 2.9) and females (BMI:21.8 ± 3.6). Measures of triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and total cholesterol (TC) (mmol/L) were also collected. The mean FA concentration seen in this cohort (11,458 ± 2478 was similar to that of overweight North American cohorts assessed in past studies. Ten biologically relevant FA were compared between sexes, with females exhibiting significantly higher concentrations in four FA (p < 0.05). A multiple regression model revealed the ten FA contributed significantly to nearly all lipid biomarkers (p < 0.05). A majority of participants who had FA concentrations in the ≥95th percentile also exhibited TG, HDL, LDL, and TC levels in the “high” risk classification of developing cardiovascular disease. Future studies profiling individual FA reference ranges in many unique, global cohorts are necessary to develop cut-off values of individual FA concentrations highly related to disease-risk. MDPI 2021-01-29 /pmc/articles/PMC7911367/ /pubmed/33572735 http://dx.doi.org/10.3390/nu13020435 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lust, Cody A. C.
Bi, Xinyan
Henry, Christiani Jeyakumar
Ma, David W. L.
Development of Fatty Acid Reference Ranges and Relationship with Lipid Biomarkers in Middle-Aged Healthy Singaporean Men and Women
title Development of Fatty Acid Reference Ranges and Relationship with Lipid Biomarkers in Middle-Aged Healthy Singaporean Men and Women
title_full Development of Fatty Acid Reference Ranges and Relationship with Lipid Biomarkers in Middle-Aged Healthy Singaporean Men and Women
title_fullStr Development of Fatty Acid Reference Ranges and Relationship with Lipid Biomarkers in Middle-Aged Healthy Singaporean Men and Women
title_full_unstemmed Development of Fatty Acid Reference Ranges and Relationship with Lipid Biomarkers in Middle-Aged Healthy Singaporean Men and Women
title_short Development of Fatty Acid Reference Ranges and Relationship with Lipid Biomarkers in Middle-Aged Healthy Singaporean Men and Women
title_sort development of fatty acid reference ranges and relationship with lipid biomarkers in middle-aged healthy singaporean men and women
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911367/
https://www.ncbi.nlm.nih.gov/pubmed/33572735
http://dx.doi.org/10.3390/nu13020435
work_keys_str_mv AT lustcodyac developmentoffattyacidreferencerangesandrelationshipwithlipidbiomarkersinmiddleagedhealthysingaporeanmenandwomen
AT bixinyan developmentoffattyacidreferencerangesandrelationshipwithlipidbiomarkersinmiddleagedhealthysingaporeanmenandwomen
AT henrychristianijeyakumar developmentoffattyacidreferencerangesandrelationshipwithlipidbiomarkersinmiddleagedhealthysingaporeanmenandwomen
AT madavidwl developmentoffattyacidreferencerangesandrelationshipwithlipidbiomarkersinmiddleagedhealthysingaporeanmenandwomen