Cargando…

Antiviral Activity of the G-Quadruplex Ligand TMPyP4 against Herpes Simplex Virus-1

The herpes simplex virus 1 (HSV-1) genome is extremely rich in guanine tracts that fold into G-quadruplexes (G4s), nucleic acid secondary structures implicated in key biological functions. Viral G4s were visualized in HSV-1 infected cells, with massive virus cycle-dependent G4-formation peaking duri...

Descripción completa

Detalles Bibliográficos
Autores principales:	Artusi, Sara, Ruggiero, Emanuela, Nadai, Matteo, Tosoni, Beatrice, Perrone, Rosalba, Ferino, Annalisa, Zanin, Irene, Xodo, Luigi, Flamand, Louis, Richter, Sara N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911665/ https://www.ncbi.nlm.nih.gov/pubmed/33525505 http://dx.doi.org/10.3390/v13020196

Ejemplares similares

The Herpes Simplex Virus-1 genome contains multiple clusters of repeated G-quadruplex: Implications for the antiviral activity of a G-quadruplex ligand
por: Artusi, Sara, et al.
Publicado: (2015)

Bcl-2 Promoter Sequence G-Quadruplex Interactions with Three Planar and Non-Planar Cationic Porphyrins: TMPyP4, TMPyP3, and TMPyP2
por: Le, Vu H., et al.
Publicado: (2013)

Visualization of DNA G-quadruplexes in herpes simplex virus 1-infected cells
por: Artusi, Sara, et al.
Publicado: (2016)

The Meta-Substituted Isomer of TMPyP Enables More Effective Photodynamic Bacterial Inactivation than Para-TMPyP In Vitro
por: Schulz, Sebastian, et al.
Publicado: (2022)

Pentose Phosphate Pathway Function Affects Tolerance to the G-Quadruplex Binder TMPyP4
por: Andrew, Elizabeth J., et al.
Publicado: (2013)

The different biological effects of TMPyP4 and cisplatin in the inflammatory microenvironment of osteosarcoma are attributed to G‐quadruplex
por: Chen, Jianqiang, et al.
Publicado: (2021)

The Interactions of H(2)TMPyP, Analogues and Its Metal Complexes with DNA G-Quadruplexes—An Overview
por: Ramos, Catarina I. V., et al.
Publicado: (2021)

Antitumor activity of G-quadruplex-interactive agent TMPyP4 with photodynamic therapy in ovarian carcinoma cells
por: LIU, HONGLI, et al.
Publicado: (2014)

Stabilization of a G-Quadruplex from Unfolding by Replication Protein A Using Potassium and the Porphyrin TMPyP4
por: Prakash, Aishwarya, et al.
Publicado: (2011)

TMPyP Inhibits Amyloid-β Aggregation and Alleviates Amyloid-Induced Cytotoxicity
por: Fan, Yujuan, et al.
Publicado: (2017)

Mass spectrometric studies on effects of counter ions of TMPyP4 on binding to human telomeric DNA and RNA G-quadruplexes
por: Bai, Li-Ping, et al.
Publicado: (2014)

Stable and Conserved G-Quadruplexes in the Long Terminal Repeat Promoter of Retroviruses
por: Ruggiero, Emanuela, et al.
Publicado: (2019)

Genome-Wide Transcriptional Response of Mycobacterium smegmatis MC(2)155 to G-Quadruplex Ligands BRACO-19 and TMPyP4
por: Shitikov, Egor, et al.
Publicado: (2022)

Characterization of the G-quadruplexes in the duplex nuclease hypersensitive element of the PDGF-A promoter and modulation of PDGF-A promoter activity by TMPyP4
por: Qin, Yong, et al.
Publicado: (2007)

A core extended naphtalene diimide G-quadruplex ligand potently inhibits herpes simplex virus 1 replication
por: Callegaro, Sara, et al.
Publicado: (2017)

Characterization of a G-quadruplex from hepatitis B virus and its stabilization by binding TMPyP4, BRACO19 and PhenDC3
por: Molnár, Orsolya Réka, et al.
Publicado: (2021)

TMPyP4, a Stabilizer of Nucleic Acid Secondary Structure, Is a Novel Acetylcholinesterase Inhibitor
por: Fujiwara, Nana, et al.
Publicado: (2015)

Quindoline-derivatives display potent G-quadruplex-mediated antiviral activity against herpes simplex virus 1
por: Frasson, Ilaria, et al.
Publicado: (2022)

TMPyP4 promotes cancer cell migration at low doses, but induces cell death at high doses
por: Zheng, Xiao-Hui, et al.
Publicado: (2016)

The quadruplex r(CGG)(n) destabilizing cationic porphyrin TMPyP4 cooperates with hnRNPs to increase the translation efficiency of fragile X premutation mRNA
por: Ofer, Noa, et al.
Publicado: (2009)

Fused in Liposarcoma Protein, a New Player in the Regulation of HIV-1 Transcription, Binds to Known and Newly Identified LTR G-Quadruplexes
por: Ruggiero, Emanuela, et al.
Publicado: (2022)

Binding of Telomestatin, TMPyP4, BSU6037, and BRACO19 to a Telomeric G-Quadruplex–Duplex Hybrid Probed by All-Atom Molecular Dynamics Simulations with Explicit Solvent
por: Sullivan, Holli-Joi, et al.
Publicado: (2018)

The cellular protein hnRNP A2/B1 enhances HIV-1 transcription by unfolding LTR promoter G-quadruplexes
por: Scalabrin, Matteo, et al.
Publicado: (2017)

Nucleolin stabilizes G-quadruplex structures folded by the LTR promoter and silences HIV-1 viral transcription
por: Tosoni, Elena, et al.
Publicado: (2015)

Telomerase Inhibitor TMPyP4 Alters Adhesion and Migration of Breast-Cancer Cells MCF7 and MDA-MB-231
por: Konieczna, Natalia, et al.
Publicado: (2019)

G-quadruplexes and G-quadruplex ligands: targets and tools in antiviral therapy
por: Ruggiero, Emanuela, et al.
Publicado: (2018)

G-Quadruplex Targeting in the Fight against Viruses: An Update
por: Ruggiero, Emanuela, et al.
Publicado: (2021)

The cellular protein nucleolin preferentially binds long-looped G-quadruplex nucleic acids()
por: Lago, Sara, et al.
Publicado: (2017)

Targeting G-quadruplexes to achieve antiviral activity
por: Ruggiero, Emanuela, et al.
Publicado: (2023)

The porphyrin TMPyP4 inhibits elongation during the noncanonical translation of the FTLD/ALS-associated GGGGCC repeat in the C9orf72 gene
por: Mori, Kohji, et al.
Publicado: (2021)

Photodynamic Activity of TMPyP4/TiO(2) Complex under Blue Light in Human Melanoma Cells: Potential for Cancer-Selective Therapy
por: Balas, Mihaela, et al.
Publicado: (2023)

Formation of a Unique Cluster of G-Quadruplex Structures in the HIV-1 nef Coding Region: Implications for Antiviral Activity
por: Perrone, Rosalba, et al.
Publicado: (2013)

Viral G-quadruplexes: New frontiers in virus pathogenesis and antiviral therapy
por: Ruggiero, Emanuela, et al.
Publicado: (2020)

The MDM2 inducible promoter folds into four-tetrad antiparallel G-quadruplexes targetable to fight malignant liposarcoma
por: Lago, Sara, et al.
Publicado: (2021)

Herpes Simplex Virus Vectors for Gene Transfer to the Central Nervous System
por: Artusi, Sara, et al.
Publicado: (2018)

Sensitive Hg(2+) Sensing via Quenching the Fluorescence of the Complex between Polythymine and 5,10,15,20-tetrakis(N-methyl-4-pyridyl) Porphyrin (TMPyP)
por: Wu, Daohong, et al.
Publicado: (2018)

Parallel G-quadruplexes recruit the HSV-1 transcription factor ICP4 to promote viral transcription in herpes virus-infected human cells
por: Frasson, Ilaria, et al.
Publicado: (2021)

Synthesis, Binding and Antiviral Properties of Potent Core-Extended Naphthalene Diimides Targeting the HIV-1 Long Terminal Repeat Promoter G-Quadruplexes
por: Perrone, Rosalba, et al.
Publicado: (2015)

Surface Plasmon Resonance kinetic analysis of the interaction between G-quadruplex nucleic acids and an anti-G-quadruplex monoclonal antibody
por: Lago, Sara, et al.
Publicado: (2018)

Effect of DNA Glycosylases OGG1 and Neil1 on Oxidized G-Rich Motif in the KRAS Promoter
por: Ferino, Annalisa, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_5474i38meaqvkmg5dnmnaqev1e