Activation of NRF2 and ATF4 Signaling by the Pro-Glutathione Molecule I-152, a Co-Drug of N-Acetyl-Cysteine and Cysteamine

I-152 combines two pro-glutathione (GSH) molecules, namely N-acetyl-cysteine (NAC) and cysteamine (MEA), to improve their potency. The co-drug efficiently increases/replenishes GSH levels in vitro and in vivo; little is known about its mechanism of action. Here we demonstrate that I-152 not only sup...

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Detalles Bibliográficos
Autores principales: Crinelli, Rita, Zara, Carolina, Galluzzi, Luca, Buffi, Gloria, Ceccarini, Chiara, Smietana, Michael, Mari, Michele, Magnani, Mauro, Fraternale, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911873/
https://www.ncbi.nlm.nih.gov/pubmed/33530504
http://dx.doi.org/10.3390/antiox10020175

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911873/
https://www.ncbi.nlm.nih.gov/pubmed/33530504
http://dx.doi.org/10.3390/antiox10020175

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