Cytokine-Coding Oncolytic Adenovirus TILT-123 Is Safe, Selective, and Effective as a Single Agent and in Combination with Immune Checkpoint Inhibitor Anti-PD-1

Oncolytic viruses provide a biologically multi-faceted treatment option for patients who cannot be cured with currently available treatment options. We constructed an oncolytic adenovirus, TILT-123, to support T-cell therapies and immune checkpoint inhibitors in solid tumors. Adenoviruses are immuno...

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Detalles Bibliográficos
Autores principales: Havunen, Riikka, Kalliokoski, Riikka, Siurala, Mikko, Sorsa, Suvi, Santos, João M., Cervera-Carrascon, Victor, Anttila, Marjukka, Hemminki, Akseli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911972/
https://www.ncbi.nlm.nih.gov/pubmed/33513935
http://dx.doi.org/10.3390/cells10020246

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911972/
https://www.ncbi.nlm.nih.gov/pubmed/33513935
http://dx.doi.org/10.3390/cells10020246

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