Repeated Administration of Clinically Relevant Doses of the Prescription Opioids Tramadol and Tapentadol Causes Lung, Cardiac, and Brain Toxicity in Wistar Rats

Tramadol and tapentadol, two structurally related synthetic opioid analgesics, are widely prescribed due to the enhanced therapeutic profiles resulting from the synergistic combination between μ-opioid receptor (MOR) activation and monoamine reuptake inhibition. However, the number of adverse reacti...

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Detalles Bibliográficos
Autores principales: Barbosa, Joana, Faria, Juliana, Garcez, Fernanda, Leal, Sandra, Afonso, Luís Pedro, Nascimento, Ana Vanessa, Moreira, Roxana, Pereira, Frederico C., Queirós, Odília, Carvalho, Félix, Dinis-Oliveira, Ricardo Jorge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912343/
https://www.ncbi.nlm.nih.gov/pubmed/33513867
http://dx.doi.org/10.3390/ph14020097

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912343/
https://www.ncbi.nlm.nih.gov/pubmed/33513867
http://dx.doi.org/10.3390/ph14020097

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