Increasing Brain Permeability of PHA-767491, a Cell Division Cycle 7 Kinase Inhibitor, with Biodegradable Polymeric Nanoparticles

A potent cell division cycle 7 (CDC7) kinase inhibitor, known as PHA-767491, has been described to reduce the transactive response DNA binding protein of 43 KDa (TDP-43) phosphorylation in vitro and in vivo, which is one of the main proteins found to aggregate and accumulate in the cytoplasm of moto...

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Detalles Bibliográficos
Autores principales: Rojas-Prats, Elisa, Tosat-Bitrián, Carlota, Martínez-González, Loreto, Nozal, Vanesa, Pérez, Daniel I., Martínez, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912371/
https://www.ncbi.nlm.nih.gov/pubmed/33525757
http://dx.doi.org/10.3390/pharmaceutics13020180

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912371/
https://www.ncbi.nlm.nih.gov/pubmed/33525757
http://dx.doi.org/10.3390/pharmaceutics13020180

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