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Ginsenoside Rg3 inhibits pulmonary fibrosis by preventing HIF-1α nuclear localisation

BACKGROUND: Excessive fibroblast proliferation during pulmonary fibrosis leads to structural abnormalities in lung tissue and causes hypoxia and cell injury. However, the mechanisms and effective treatment are still limited. METHODS: In vivo, we used bleomycin to induce pulmonary fibrosis in mice. I...

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Detalles Bibliográficos
Autores principales: Fu, Zhuo, Xu, Yong-sheng, Cai, Chun-quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912494/
https://www.ncbi.nlm.nih.gov/pubmed/33639908
http://dx.doi.org/10.1186/s12890-021-01426-5