Cargando…

The Pancreatic β-Cell: The Perfect Redox System

Pancreatic β-cell insulin secretion, which responds to various secretagogues and hormonal regulations, is reviewed here, emphasizing the fundamental redox signaling by NADPH oxidase 4- (NOX4-) mediated H(2)O(2) production for glucose-stimulated insulin secretion (GSIS). There is a logical summation...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ježek, Petr, Holendová, Blanka, Jabůrek, Martin, Tauber, Jan, Dlasková, Andrea, Plecitá-Hlavatá, Lydie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912581/ https://www.ncbi.nlm.nih.gov/pubmed/33572903 http://dx.doi.org/10.3390/antiox10020197

Ejemplares similares

Contribution of Mitochondria to Insulin Secretion by Various Secretagogues
por: Ježek, Petr, et al.
Publicado: (2022)

Redox Homeostasis in Pancreatic β Cells
por: Ježek, Petr, et al.
Publicado: (2012)

Fatty Acid-Stimulated Insulin Secretion vs. Lipotoxicity
por: Ježek, Petr, et al.
Publicado: (2018)

Redox Signaling from Mitochondria: Signal Propagation and Its Targets
por: Ježek, Petr, et al.
Publicado: (2020)

Redox Homeostasis in Pancreatic β-Cells: From Development to Failure
por: Benáková, Štěpánka, et al.
Publicado: (2021)

Potential of Mitochondria-Targeted Antioxidants to Prevent Oxidative Stress in Pancreatic β-cells
por: Plecitá-Hlavatá, Lydie, et al.
Publicado: (2019)

Contribution of Oxidative Stress and Impaired Biogenesis of Pancreatic β-Cells to Type 2 Diabetes
por: Ježek, Petr, et al.
Publicado: (2019)

Mitochondrial Superoxide Production Decreases on Glucose-Stimulated Insulin Secretion in Pancreatic β Cells Due to Decreasing Mitochondrial Matrix NADH/NAD(+) Ratio
por: Plecitá-Hlavatá, Lydie, et al.
Publicado: (2020)

Mitochondrial Cristae Morphology Reflecting Metabolism, Superoxide Formation, Redox Homeostasis, and Pathology
por: Ježek, Petr, et al.
Publicado: (2023)

Cysteine residues in signal transduction and its relevance in pancreatic beta cells
por: Holendova, Blanka, et al.
Publicado: (2023)

Glucose-Induced Expression of DAPIT in Pancreatic β-Cells
por: Leguina-Ruzzi, Alberto, et al.
Publicado: (2020)

Mitochondrial Uncoupling Proteins: Subtle Regulators of Cellular Redox Signaling
por: Ježek, Petr, et al.
Publicado: (2018)

Aglycemic HepG2 Cells Switch From Aminotransferase Glutaminolytic Pathway of Pyruvate Utilization to Complete Krebs Cycle at Hypoxia
por: Ježek, Jan, et al.
Publicado: (2018)

Antioxidant Role and Cardiolipin Remodeling by Redox-Activated Mitochondrial Ca(2+)-Independent Phospholipase A(2)γ in the Brain
por: Průchová, Pavla, et al.
Publicado: (2022)

H(2)O(2)-Activated Mitochondrial Phospholipase iPLA(2)γ Prevents Lipotoxic Oxidative Stress in Synergy with UCP2, Amplifies Signaling via G-Protein–Coupled Receptor GPR40, and Regulates Insulin Secretion in Pancreatic β-Cells
por: Ježek, Jan, et al.
Publicado: (2015)

Antioxidant Synergy of Mitochondrial Phospholipase PNPLA8/iPLA2γ with Fatty Acid–Conducting SLC25 Gene Family Transporters
por: Jabůrek, Martin, et al.
Publicado: (2021)

Overexpression of native IF1 downregulates glucose-stimulated insulin secretion by pancreatic INS-1E cells
por: Kahancová, Anežka, et al.
Publicado: (2020)

Cytoprotective activity of mitochondrial uncoupling protein‐2 in lung and spleen
por: Jabůrek, Martin, et al.
Publicado: (2018)

Hallmarks of Pulmonary Hypertension: Mesenchymal and Inflammatory Cell Metabolic Reprogramming
por: D'Alessandro, Angelo, et al.
Publicado: (2018)

The role of m(6)A and m(6)Am RNA modifications in the pathogenesis of diabetes mellitus
por: Benak, Daniel, et al.
Publicado: (2023)

Microenvironmental regulation of T-cells in pulmonary hypertension
por: Plecitá-Hlavatá, Lydie, et al.
Publicado: (2023)

Nkx6.1 decline accompanies mitochondrial DNA reduction but subtle nucleoid size decrease in pancreatic islet β-cells of diabetic Goto Kakizaki rats
por: Špaček, Tomáš, et al.
Publicado: (2017)

Possible frequent multiple mitochondrial DNA copies in a single nucleoid in HeLa cells
por: Pavluch, Vojtěch, et al.
Publicado: (2023)

Mitochondrial Redox Regulations and Redox Biology of Mitochondria
por: Ježek, Petr
Publicado: (2021)

SIRT3 and GCN5L regulation of NADP+- and NADPH-driven reactions of mitochondrial isocitrate dehydrogenase IDH2
por: Smolková, Katarína, et al.
Publicado: (2020)

Pitfalls of Mitochondrial Redox Signaling Research
por: Ježek, Petr
Publicado: (2023)

Fatty Acids are Key in 4-Hydroxy-2-Nonenal-Mediated Activation of Uncoupling Proteins 1 and 2
por: Malingriaux, Elena A., et al.
Publicado: (2013)

Targeting redox metabolism: the perfect storm induced by acrylamide poisoning in the brain
por: Raldúa, Demetrio, et al.
Publicado: (2020)

Characterization of the S100A1 Protein Binding Site on TRPC6 C-Terminus
por: Bily, Jan, et al.
Publicado: (2013)

Integrative Binding Sites within Intracellular Termini of TRPV1 Receptor
por: Grycova, Lenka, et al.
Publicado: (2012)

Perfection
Publicado: (1890)

Diabetic Ketoacidosis and Hypertriglyceridemiainduced Pancreatitis: Can the Perfect Storm Happen Twice?
por: Tiperneni, Raghu, et al.
Publicado: (2022)

2-Hydroxyglutarate in Cancer Cells
por: Ježek, Petr
Publicado: (2020)

Geniposide Balances the Redox Signaling to Mediate Glucose-Stimulated Insulin Secretion in Pancreatic β-Cells
por: Liu, Chunyan, et al.
Publicado: (2020)

Perfect simulation
por: Huber, Mark L
Publicado: (2015)

The perfectibility of man
por: Passmore, John Arthur
Publicado: (1972)

The Perfect Wagnerite/
por: Shaw, George Bernard

The idiocy of perfection /
por: Silva-Herzog Márquez, Jesús J., 1965-
Publicado: (2017)

Perfect groups
por: Holt, Derek F, et al.
Publicado: (1989)

Perfect French
por: Thomas, Michel
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_433ps184n5f4s6nvqfmmb7dcu0