Protopine/Gemcitabine Combination Induces Cytotoxic or Cytoprotective Effects in Cell Type-Specific and Dose-Dependent Manner on Human Cancer and Normal Cells

The natural alkaloid protopine (PRO) exhibits pharmacological properties including anticancer activity. We investigated the effects of PRO, alone and in combination with the chemotherapeutic gemcitabine (GEM), on human tumor cell lines and non-tumor human dermal fibroblasts (HDFs). We found that tre...

Descripción completa

Detalles Bibliográficos
Autores principales: Garcia-Gil, Mercedes, Turri, Benedetta, Gabriele, Morena, Pucci, Laura, Agnarelli, Alessandro, Lai, Michele, Freer, Giulia, Pistello, Mauro, Vignali, Robert, Batistoni, Renata, Marracci, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912662/
https://www.ncbi.nlm.nih.gov/pubmed/33530428
http://dx.doi.org/10.3390/ph14020090

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912662/
https://www.ncbi.nlm.nih.gov/pubmed/33530428
http://dx.doi.org/10.3390/ph14020090

Ejemplares similares