Cargando…

Design, Synthesis, Anticancer Activity, and Solid Lipid Nanoparticle Formulation of Indole- and Benzimidazole-Based Compounds as Pro-Apoptotic Agents Targeting Bcl-2 Protein

Cancer is a multifactorial disease necessitating identification of novel targets for its treatment. Inhibition of Bcl-2 for triggered pro-apoptotic signaling is considered a promising strategy for cancer treatment. Within the current work, we aimed to design and synthesize a new series of benzimidaz...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nagy, Manar I., Darwish, Khaled M., Kishk, Safaa M., Tantawy, Mohamed A., Nasr, Ali M., Qushawy, Mona, Swidan, Shady A., Mostafa, Samia M., Salama, Ismail
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912796/ https://www.ncbi.nlm.nih.gov/pubmed/33535550 http://dx.doi.org/10.3390/ph14020113

Ejemplares similares

Design, Optimization and Characterization of a Transfersomal Gel Using Miconazole Nitrate for the Treatment of Candida Skin Infections
por: Qushawy, Mona, et al.
Publicado: (2018)

Preparation and Evaluation of Carbamazepine Solid Lipid Nanoparticle for Alleviating Seizure Activity in Pentylenetetrazole-Kindled Mice
por: Qushawy, Mona, et al.
Publicado: (2019)

Quality by Design for the Development and Analysis of Enhanced In-Situ Forming Vesicles for the Improvement of the Bioavailability of Fexofenadine HCl In Vitro and In Vivo
por: Nasr, Ali M., et al.
Publicado: (2020)

In Silico and In Vitro Studies for Benzimidazole Anthelmintics Repurposing as VEGFR-2 Antagonists: Novel Mebendazole-Loaded Mixed Micelles with Enhanced Dissolution and Anticancer Activity
por: Elmaaty, Ayman Abo, et al.
Publicado: (2021)

Design, Synthesis, and Potent Anticancer Activity of Novel Indole-Based Bcl-2 Inhibitors
por: Almehdi, Ahmed M., et al.
Publicado: (2023)

Celecoxib Loaded In-Situ Provesicular Powder and Its In-Vitro Cytotoxic Effect for Cancer Therapy: Fabrication, Characterization, Optimization and Pharmacokinetic Evaluation
por: Nasr, Ali M., et al.
Publicado: (2020)

Comparative Estimation of the Cytotoxic Activity of Different Parts of Cynara scolymus L.: Crude Extracts versus Green Synthesized Silver Nanoparticles with Apoptotic Investigation
por: Khedr, Amgad I. M., et al.
Publicado: (2022)

Indole and Benzimidazole Bichalcophenes: Synthesis, DNA Binding and Antiparasitic Activity
por: Farahat, Abdelbasset A., et al.
Publicado: (2018)

The Anticancer Activity for the Bumetanide-Based Analogs via Targeting the Tumor-Associated Membrane-Bound Human Carbonic Anhydrase-IX Enzyme
por: Malebari, Azizah M., et al.
Publicado: (2020)

Lipid based nanoparticles as a novel treatment modality for hepatocellular carcinoma: a comprehensive review on targeting and recent advances
por: Mahmoud, Khaled, et al.
Publicado: (2022)

Development, Optimization, and In Vitro/In Vivo Evaluation of Azelaic Acid Transethosomal Gel for Antidermatophyte Activity
por: Nasr, Ali M., et al.
Publicado: (2023)

BCL-w: apoptotic and non-apoptotic role in health and disease
por: Hartman, Mariusz L., et al.
Publicado: (2020)

Trazodone Loaded Lipid Core Poly (ε-caprolactone) Nanocapsules: Development, Characterization and in Vivo Antidepressant Effect Evaluation
por: Elhesaisy, Nahla, et al.
Publicado: (2020)

Design and Synthesis of New Quinoxaline Derivatives as Anticancer Agents and Apoptotic Inducers
por: El Newahie, Aliya M. S., et al.
Publicado: (2019)

New Quinoline-Based Heterocycles as Anticancer Agents Targeting Bcl-2
por: Hamdy, Rania, et al.
Publicado: (2019)

Design and Synthesis of Benzimidazole-Chalcone Derivatives as Potential Anticancer Agents
por: Hsieh, Cheng-Ying, et al.
Publicado: (2019)

Evolution of the BCL-2-Regulated Apoptotic Pathway
por: Aouacheria, Abdel, et al.
Publicado: (2016)

Anticancer Indole-Based Chalcones: A Structural and Theoretical Analysis
por: Badria, Farid A., et al.
Publicado: (2019)

Anti-apoptotic gene Bcl2 is required for stapes development and hearing
por: Carpinelli, M R, et al.
Publicado: (2012)

Polyubiquitination and proteasomal turnover controls the anti-apoptotic activity of Bcl-B
por: van de Kooij, B, et al.
Publicado: (2013)

Visible Light Promotes Cascade Trifluoromethylation/Cyclization, Leading to Trifluoromethylated Polycyclic Quinazolinones, Benzimidazoles and Indoles
por: Ma, Ransong, et al.
Publicado: (2022)

Anti-apoptotic BCL-2 family proteins in acute neural injury
por: Anilkumar, Ujval, et al.
Publicado: (2014)

Silver Nanoparticles Formulation of Flower Head’s Polyphenols of Cynara scolymus L.: A Promising Candidate against Prostate (PC-3) Cancer Cell Line through Apoptosis Activation
por: Khedr, Amgad I. M., et al.
Publicado: (2022)

In-silico molecular design of heterocyclic benzimidazole scaffolds as prospective anticancer agents
por: Tahlan, Sumit, et al.
Publicado: (2019)

Indole and 2,4-Thiazolidinedione conjugates as potential anticancer modulators
por: Corigliano, Domenica M., et al.
Publicado: (2018)

Anti-apoptotic BCL-2 family members in development
por: Opferman, Joseph T, et al.
Publicado: (2018)

Synthesis, molecular modeling and anticancer activity of new coumarin containing compounds
por: Morsy, Shaimaa A., et al.
Publicado: (2017)

Pharmacological evaluation of new constituents of “Spice”: synthetic cannabinoids based on indole, indazole, benzimidazole and carbazole scaffolds
por: Schoeder, Clara T., et al.
Publicado: (2018)

Comparative Studies on Conventional and Microwave Synthesis of Some Benzimidazole, Benzothiazole and Indole Derivatives and Testing on Inhibition of Hyaluronidase
por: Algul, Oztekin, et al.
Publicado: (2008)

Nrz but not zBcl-xL antagonizes Bcl-wav pro-apoptotic activity in zebrafish
por: Prudent, Julien, et al.
Publicado: (2014)

Post-ingestion conversion of dietary indoles into anticancer agents
por: Lin, Li Ping, et al.
Publicado: (2021)

Synthesis and Anticancer Activity of Indole-Functionalized Derivatives of Betulin
por: Rzepka, Zuzanna, et al.
Publicado: (2022)

Design, Synthesis and Evaluation of New Bioactive Oxadiazole Derivatives as Anticancer Agents Targeting Bcl-2
por: Hamdy, Rania, et al.
Publicado: (2020)

Critical role of anti-apoptotic Bcl-2 protein phosphorylation in mitotic death
por: Eichhorn, J M, et al.
Publicado: (2013)

IRES-mediated translation of the pro-apoptotic Bcl2 family member PUMA
por: Shaltouki, Atossa, et al.
Publicado: (2013)

Evaluation of Transition Metal Complexes of Benzimidazole-Derived Scaffold as Promising Anticancer Chemotherapeutics
por: Hussain, Afzal, et al.
Publicado: (2018)

The Bcl-2 repertoire of mesothelioma spheroids underlies acquired apoptotic multicellular resistance
por: Barbone, D, et al.
Publicado: (2011)

New Bioactive Fused Triazolothiadiazoles as Bcl-2-Targeted Anticancer Agents
por: Hamdy, Rania, et al.
Publicado: (2021)

Characterization, antibacterial, antioxidant, antidiabetic, and anti-inflammatory activities of green synthesized silver nanoparticles using Phragmanthera austroarabica A. G. Mill and J. A. Nyberg extract
por: Khodeer, Dina M., et al.
Publicado: (2023)

Levels of pro-apoptotic regulator Bad and anti-apoptotic regulator Bcl-xL determine the type of the apoptotic logic gate
por: Bogdał, Marta N, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_d39ilaoh5115qobl8qtb72o051