Population Pharmacokinetic Method to Predict Within-Subject Variability Using Single-Period Clinical Data

Sample sizes for single-period clinical trials, including pharmacokinetic studies, are statistically determined by within-subject variability (WSV). However, it is difficult to determine WSV without replicate-designed clinical trial data, and statisticians typically estimate optimal sample sizes usi...

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Detalles Bibliográficos
Autores principales: Kang, Won-ho, Lee, Jae-yeon, Chae, Jung-woo, Lee, Kyeong-Ryoon, Baek, In-hwan, Kim, Min-Soo, Back, Hyun-moon, Jung, Sangkeun, Shaffer, Craig, Savic, Rada, Yun, Hwi-yeol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913178/
https://www.ncbi.nlm.nih.gov/pubmed/33546114
http://dx.doi.org/10.3390/ph14020114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913178/
https://www.ncbi.nlm.nih.gov/pubmed/33546114
http://dx.doi.org/10.3390/ph14020114

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