Cargando…

Synthesis and Anti-Hepatocarcinoma Effect of Amino Acid Derivatives of Pyxinol and Ocotillol

Aiming at seeking an effective anti-hepatocarcinoma drug with low toxicity, a total of 24 amino acid derivatives (20 new along with 4 known derivatives) of two active ocotillol-type sapogenins (pyxinol and ocotillol) were synthesized. Both in vitro and in vivo anti-hepatocarcinoma effects of derivat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Ying, Yu, Hui, Fu, Shuzheng, Tan, Luying, Liu, Junli, Zhou, Baisong, Li, Le, Liu, Yunhe, Wang, Caixia, Li, Pingya, Liu, Jinping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913291/ https://www.ncbi.nlm.nih.gov/pubmed/33546225 http://dx.doi.org/10.3390/molecules26040780

Ejemplares similares

Protective Effect of Ocotillol, the Derivate of Ocotillol-Type Saponins in Panax Genus, against Acetic Acid-Induced Gastric Ulcer in Rats Based on Untargeted Metabolomics
por: Wang, Cuizhu, et al.
Publicado: (2020)

Study on the Comprehensive Phytochemicals and the Anti-Ulcerative Colitis Effect of Saussurea pulchella
por: Liu, Yunhe, et al.
Publicado: (2023)

Synthesis and Antibacterial Evaluation of Novel 3-Substituted Ocotillol-Type Derivatives as Leads
por: Bi, Yi, et al.
Publicado: (2017)

Comprehensive metabolomics analysis based on UPLC-Q/TOF-MS(E) and the anti-COPD effect of different parts of Celastrus orbiculatus Thunb.
por: Yang, Na, et al.
Publicado: (2020)

Integrated Metabolomics and Network Pharmacology to Decipher the Latent Mechanisms of Protopanaxatriol against Acetic Acid-Induced Gastric Ulcer
por: Wang, Cuizhu, et al.
Publicado: (2022)

Design, Synthesis and Antibacterial Evaluation of 3-Substituted Ocotillol-Type Derivatives
por: Wang, Kai-Yi, et al.
Publicado: (2018)

UPLC-QTOF-MS-guided isolation of anti-COPD ginsenosides from wild ginseng
por: Zhu, Hailin, et al.
Publicado: (2019)

Discovery, semisynthesis, biological activities, and metabolism of ocotillol-type saponins
por: Liu, Juan, et al.
Publicado: (2017)

Protective Effect of Ethyl Rosmarinate against Ulcerative Colitis in Mice Based on Untargeted Metabolomics
por: Zhou, Baisong, et al.
Publicado: (2022)

Design, Synthesis, and Antibacterial Evaluation of Novel Ocotillol Derivatives and Their Synergistic Effects with Conventional Antibiotics
por: Zhang, Doudou, et al.
Publicado: (2021)

Recent Advances in the Semisynthesis, Modifications and Biological Activities of Ocotillol-Type Triterpenoids
por: Cao, Yucheng, et al.
Publicado: (2020)

Ocotillol Enhanced the Antitumor Activity of Doxorubicin via p53-Dependent Apoptosis
por: Wang, Hongbo, et al.
Publicado: (2013)

Protective Effect of Pyxinol, One Active Ingredient of Lichenes on Cisplatin-Induced Nephrotoxicity via Ameliorating DNA Damage Response
por: Yang, Yanting, et al.
Publicado: (2021)

Comprehensive Metabolomics Analysis of Xueshuan Xinmaining Tablet in Blood Stasis Model Rats Using UPLC-Q/TOF-MS
por: Tan, Jing, et al.
Publicado: (2018)

Comparative genomics reveals the diversification of triterpenoid biosynthesis and origin of ocotillol-type triterpenes in Panax
por: Yang, Zijiang, et al.
Publicado: (2023)

Stereoselective Property of 20(S)-Protopanaxadiol Ocotillol Type Epimers Affects Its Absorption and Also the Inhibition of P-Glycoprotein
por: Wang, Wenyan, et al.
Publicado: (2014)

Effects of R type and S type ginsenoside Rg3 on DNA methylation in human hepatocarcinoma cells
por: Teng, Siying, et al.
Publicado: (2017)

Pharmacokinetic and Metabolism Studies of 12-Riboside-Pseudoginsengenin DQ by UPLC-MS/MS and UPLC-QTOF-MS(E)
por: Wang, Zhenzhou, et al.
Publicado: (2018)

Semi-synthetic ocotillol analogues as selective ABCB1-mediated drug resistance reversal agents
por: Zhang, Yun-Kai, et al.
Publicado: (2015)

Non-Targeted Metabolomic Analysis of Methanolic Extracts of Wild-Simulated and Field-Grown American Ginseng
por: Lin, Hongqiang, et al.
Publicado: (2019)

Pseudoginsengenin DQ Exhibits Therapeutic Effects in Cisplatin-Induced Acute Kidney Injury via Sirt1/NF-κB and Caspase Signaling Pathway without Compromising Its Antitumor Activity in Mice
por: Qi, Zeng, et al.
Publicado: (2018)

Discovery of the Potential Biomarkers for Discrimination between Hedyotis diffusa and Hedyotis corymbosa by UPLC-QTOF/MS Metabolome Analysis
por: Wang, Yaru, et al.
Publicado: (2018)

UPLC-QTOF/MS-Based Nontargeted Metabolomic Analysis of Mountain- and Garden-Cultivated Ginseng of Different Ages in Northeast China
por: Zhu, Hailin, et al.
Publicado: (2018)

Novel Functionalized Selenium Nanoparticles for Enhanced Anti-Hepatocarcinoma Activity In vitro
por: Xia, Yu, et al.
Publicado: (2015)

Bioactivity-guided isolation of antioxidant and anti-hepatocarcinoma constituents from Veronica ciliata
por: Yin, Li, et al.
Publicado: (2016)

Protective Effects of Protopanaxatriol Saponins on Ulcerative Colitis in Mouse Based on UPLC-Q/TOF-MS Serum and Colon Metabolomics
por: Wu, Fulin, et al.
Publicado: (2022)

Transcriptome analysis of Panax vietnamensis var. fuscidicus discovers putative ocotillol-type ginsenosides biosynthesis genes and genetic markers
por: Zhang, Guang-Hui, et al.
Publicado: (2015)

High efficacy and minimal peptide required for the anti-angiogenic and anti-hepatocarcinoma activities of plasminogen K5
por: Yang, Xia, et al.
Publicado: (2010)

Correction to: Novel Functionalized Selenium Nanoparticles for Enhanced Anti-Hepatocarcinoma Activity In vitro
por: Xia, Yu, et al.
Publicado: (2022)

Identification of blood-activating components from Xueshuan Xinmaining Tablet based on the spectrum–effect relationship and network pharmacology analysis
por: Tan, Jing, et al.
Publicado: (2020)

Synthesis of magnolol and honokiol derivatives and their effect against hepatocarcinoma cells
por: Maioli, Margherita, et al.
Publicado: (2018)

Metformin sensitises hepatocarcinoma cells to methotrexate by targeting dihydrofolate reductase
por: Wang, Yinghui, et al.
Publicado: (2021)

Phenotypic Characterization Analysis of Human Hepatocarcinoma by Urine Metabolomics Approach
por: Liang, Qun, et al.
Publicado: (2016)

Visible-light photoredox synthesis of unnatural chiral α-amino acids
por: Jiang, Min, et al.
Publicado: (2016)

Anti-Metastasis Effect of Fucoidan from Undaria pinnatifida Sporophylls in Mouse Hepatocarcinoma Hca-F Cells
por: Wang, Peisheng, et al.
Publicado: (2014)

Homogenous multifunctional microspheres induce ferroptosis to promote the anti-hepatocarcinoma effect of chemoembolization
por: Chen, Minjiang, et al.
Publicado: (2022)

Inhibition of autophagy enhances anticancer effects of bevacizumab in hepatocarcinoma
por: Guo, Xian-ling, et al.
Publicado: (2012)

Immunomodulatory Effects of (24R)-Pseudo-Ginsenoside HQ and (24S)-Pseudo-Ginsenoside HQ on Cyclophosphamide-Induced Immunosuppression and Their Anti-Tumor Effects Study
por: Qi, Zeng, et al.
Publicado: (2019)

Hepatocyte-targeting and tumor microenvironment-responsive liposomes for enhanced anti-hepatocarcinoma efficacy
por: Cheng, Dongliang, et al.
Publicado: (2022)

Multicystic Hepatocarcinoma Mimicking Liver Abscess
por: Falidas, Evangelos, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_87s69do99ka39fdcbbrl0lp7hc