Identification and characterization of heteroclitic peptides in TCR-binding positions with improved HLA-binding efficacy

The antigenicity as well as the immunogenicity of tumor associated antigens (TAAs) may need to be potentiated in order to break the immunological tolerance. To this aim, heteroclitic peptides were designed introducing specific substitutions in the residue at position 4 (p4) binding to TCR. The effec...

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Detalles Bibliográficos
Autores principales: Cavalluzzo, Beatrice, Ragone, Concetta, Mauriello, Angela, Petrizzo, Annacarmen, Manolio, Carmen, Caporale, Andrea, Vitagliano, Luigi, Ruvo, Menotti, Buonaguro, Luigi, Tagliamonte, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913412/
https://www.ncbi.nlm.nih.gov/pubmed/33637105
http://dx.doi.org/10.1186/s12967-021-02757-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913412/
https://www.ncbi.nlm.nih.gov/pubmed/33637105
http://dx.doi.org/10.1186/s12967-021-02757-x

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