FOXO1 mitigates the SMAD3/FOXL2(C134W) transcriptomic effect in a model of human adult granulosa cell tumor

BACKGROUND: Adult granulosa cell tumor (aGCT) is a rare type of stromal cell malignant cancer of the ovary characterized by elevated estrogen levels. aGCTs ubiquitously harbor a somatic mutation in FOXL2 gene, Cys134Trp (c.402C < G); however, the general molecular effect of this mutation and its...

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Detalles Bibliográficos
Autores principales: Secchi, Christian, Benaglio, Paola, Mulas, Francesca, Belli, Martina, Stupack, Dwayne, Shimasaki, Shunichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913442/
https://www.ncbi.nlm.nih.gov/pubmed/33639972
http://dx.doi.org/10.1186/s12967-021-02754-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913442/
https://www.ncbi.nlm.nih.gov/pubmed/33639972
http://dx.doi.org/10.1186/s12967-021-02754-0

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